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Don't use alpha-lipoic acid if you're a heavy alcohol user. Serum folate, vitamin B12 levels and diabetic peripheral neuropathy in type 2 diabetes: A meta-analysis. One study found, however, that people taking alpha-lipoic acid orally may develop a rash (5). Neurological examination. https://nccih.nih.gov/health/diabetes/supplements. Although research into the relationship between dietary supplements and diabetic neuropathy is ongoing, eating a healthy diet is widely recognized as a key part of managing your blood sugar and diabetes complications such as diabetic neuropathy. Note: This document contains side effect information about alpha-lipoic acid. Mayo clinic study finds alpha lipoic acid decreases burning pain and numbness of neuropathy A collaborative study between Mayo Clinic and a medical center in Russia found that alpha lipoic acid (ALA) significantly and rapidly reduces the frequency and severity of symptoms of the most common kind of diabetic neuropathy. However, for people who don't have a vitamin B-12 deficiency, taking B-12 supplements for diabetic neuropathy hasn't been shown to help. This article provides information regarding the same. Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; A single copy of these materials may be reprinted for noncommercial personal use only. tingling and a feeling of 'pins and needles' under the skin Excess doses of alpha lipoic acid can cause low blood sugar levels. Some may notice mild insomnia, fatigue, upset stomach, diarrhea, dizziness, and/or skin rash. Accessed April 7, 2020. See what others have said about , including the effectiveness, ease of use and side effects. Mayo Clinic does not endorse companies or products. Molecular and Cellular Endocrinology. received an overall rating of 4 out of 10 stars from 10 reviews. The Side Effects of Alpha Lipoic Acid. Disorders of peripheral nerves. Alpha-lipoic acid. Accessed April 7, 2020. But higher doses could cause skin rash, nausea or stomach upset, along with nervousness, fatigue and insomnia. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. Side effects only start to be felt at higher doses. Alpha-lipoic acid is used for diabetes and nerve-related symptoms of diabetes including burning, pain, and numbness in the legs and arms. Accessed April 7, 2020. multivitamin, biotin, ascorbic acid, calcium / vitamin d, Fish Oil. Alpha-lipoic acid is an antioxidant found in many foods. … You may report side effects to the FDA at 1-800-332-1088. Acetyl-L-carnitine is a chemical compound naturally produced in the kidneys and liver. The Mayo Clinic recommends not using ALA if you are a heavy user of alcohol. Alpha lipoic acid is generally a safe supplement to take however there are few potential dangers a user should be made aware of. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. Alpha-lipoic acid also has been shown to lower blood sugar levels. 2017; doi:10.1016/S2213-8587(17)30014-1. Mayo Clinic offers appointments in Arizona, Florida and Minnesota and at Mayo Clinic Health System locations. A vitamin B-12 supplement is generally considered safe when taken as directed. And be sure to wear comfortable, supportive shoes. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. However, many people have no side effects or only have minor side effects. help if you have any side effects that bother you or do not go away. tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, Exercise management in type 1 diabetes: A consensus statement. Wang D, et al. For example, aim to go on a brisk walk for about 30 minutes on most days of the week. The Lancet. Side effects may include nausea, vomiting or agitation. Side effects of ALA supplementation are generally mild and include a skin rash. Dietary supplements may help reduce diabetic neuropathy symptoms, but more research is needed. There are few reported side effects of alpha lipoic acid when taken at dosage levels recommended by the suppliers. Alpha-lipoic acid is generally considered safe when taken as an oral supplement or used as a topical ointment. ... Stop taking ALA immediately if you notice any unusual side effects … Natural sources of alpha-lipoic acid include spinach, broccoli and yeast. People deficient in thiamine, which is associated with long-term alcohol abuse, should not take alpha-lipoic acid … https://ww.naturaldatabase.com. 2. Daroff RB, et al. Accessed April 7, 2020. This condition can cause pain and tingling in the hands and feet, digestion problems, and sexual problems. Advanced neuropathy in the feet can lead to: Eating a healthy diet is an important part of managing your diabetes, and it may help prevent diabetic neuropathy and other complications. Please consult with your healthcare provider before starting a new diet or supplement. Our general interest e-newsletter keeps you up to date on a wide variety of health topics. https://ods.od.nih.gov/factsheets/Carnitine-HealthProfessional/. In: Bradley's Neurology in Clinical Practice. Carnitine: Fact sheet for health professionals. Alpha-lipoic acid is a natural compound with antioxidant properties and other potential health benefits. In a few small studies, people who had diabetic neuropathy experienced less pain, improved performance on nerve function tests, and improvements in other signs and symptoms. Natural Medicines Comprehensive Database. Side Effects & Safety When taken by mouth: Alpha-lipoic acid is POSSIBLY SAFE for most adults when taken for up to 4 years. What are some side effects that I need to call my doctor about right away? According to Dr. Sahelian, low doses of lipoic acid, such as 5 to 20 mg, show no side effects. Available for Android and iOS devices. In recent years, antioxidant supplements like CoQ10 and alpha lipoic… Your doctor will review your medical history, including your symptoms, your lifestyle, exposure to toxins, drinking habits and a family history of nervous system (neurological) diseases. Alpha-lipoic acid is a natural protective antioxidant. Source: Alpha Lipoic Acid: Top 10 Benefits & Possible Side Effects by Dr. Edward Group Antioxidants are nutrients that counteract the natural deterioration of cells. https://naturalmedicines.therapeuticresearch.com. Alpha lipoic acid is beneficial as health supplement for healthy people and also in … … People who have diabetes should aim for at least 150 minutes of moderate to vigorous activity each week. It's most often used to help with diabetic neuropathy, which is a condition where you lose feeling in areas of your body as a complication of diabetes, like numbness, tingling, and burning pains in your legs and feet. Besides a physical exam, which may include blood tests, diagnosis usually requires: 1. Some side effects may not be reported. Studies show it may help with symptoms of diabetes, cancer treatments, and other conditions. 2016; doi:10.11622/smedj.2016027. Alpha Lipoic Acid Call your doctor or get medical doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect: All drugs may cause side effects. If you have questions about side effects, call your doctor. All rights reserved. Call your doctor for medical ... Side effects may include nausea, vomiting or agitation. Vitamin B supplementation for diabetic peripheral neuropathy. Check with your doctor before starting a new physical activity, especially if you're taking medications that lower your blood sugar. ALA is generally considered safe, however, some precautions should be taken while using this supplement, according to the University of Maryland Medical Center. People taking alpha-lipoic acid by mouth might get a rash. Diabetic neuropathy is a type of nerve damage that can happen if you have diabetes. Carpal tunnel exercises: Can they relieve symptoms? This content does not have an English version. Applies to alpha-lipoic acid: oral tablet. Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education. Drink water before, during and after activity to prevent dehydration. It can be detected in all cells of a living organism, where it participates in the means of energy generation. What is alpha lipoic acid used for? Alpha-lipoic acid supplements are generally considered safe when taken as recommended. Vitamin B12: Dietary supplement fact sheet. Hypothyroidism: Can it cause peripheral neuropathy? More studies are needed. Alpha-lipoic acid side effects. Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission. Alpha-lipoic acid may cause skin issues. Animal studies suggest alpha lipoic acid can also help protect the heart from the toxic side effects of the chemotherapy drug doxorubicin. The biologically active substance acetyl-l-carnitine alpha lipoic acid, which is … In addition, usnic acid has been found to have in vitro antiproliferative activity.12x12Ingolfsdottir, K. Usnic acid. Accessed April 2, 2020. In general, alpha lipoic acid (ALA) is considered a safe supplement to take. Natural Medicines. Some may interfere with certain diabetes medications, and some can increase the risk of kidney problems. Although not all side effects are known, alpha-lipoic acid is thought to be possibly safe when taken as directed. A healthy diet is a critical factor in controlling blood sugar, which is key in managing diabetes and preventing or slowing the progression of diabetes complications such as diabetic neuropathy. Alpha-lipoic acid is a naturally occurring antioxidant our bodies produce, and when taken as recommended there are no negative side-effects. In addition, alpha lipoic acid's direct antioxidant and metal chelating properties also seem to enhance the drug's antitumor effects. However, there is little research exploring the long-term safety of alpha-lipoic acid, including at what point the supplement may become toxic. The S-form occurs when alpha lipoic acid is synthetically manufactured, creating both the S-form and the active R-form. Note: This document contains side effect information about alpha-lipoic acid. This content does not have an Arabic version. Usnic acid and its derivatives have been studied for their antibacterial, antifungal, and antiprotozoal effects. Antioxidants are substances that the body can use to prevent or manage a tissue-damaging process (oxidative stress). . See our safe care and visitor guidelines, plus trusted coronavirus information. Alpha-lipoic acid supplements are generally considered safe when taken as recommended. Raw, organic fruits and vegetables provide a wide array of antioxidants. WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Side effects of alpha lipoic acid are generally rare. Diabetes diet, eating, & physical activity. Are There Any Known Alpha Lipoic Acid Side Effects? Use in pregnant or lactating women is not recommended. In a few clinical trials, people who had diabetic neuropathy had reduced pain, improvements in other sensory problems and improvements in nerve function tests. When ALA is used in hangover treatments, ALA’s natural anti-inflammatory and antioxidant properties help break down the … People who don't get enough vitamin B-12 may have a higher risk of neuropathy and other nervous system (neurological) problems. National Center for Complementary and Integrative Health. Diabetic neuropathy: Can dietary supplements help? Antioxidants are also present in herbs like astragalus root and Tibetan Rhodiola. Oxidative stress is a part of the diabetic neuropathy disease process. Other reactions include: Natural Medicines. Diabetes and dietary supplements: In depth. Signs of low blood sugar like dizziness, headache, feeling sleepy, feeling weak, shaking, a fast heartbeat, confusion, hunger, or sweating. Side effects: Side effects are rare and toxicity risk is very low. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Accessed April 7, 2020. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. https://naturalmedicines.therapeuticresearch.com. There have, in fact, been several reports of seizures and vomiting in children who have taken doses of 2,400 mg or greater.8 Common side effects of alpha-lipoic acid may include a headache, skin rash, muscle cramp, or a tingling "pins and needles" sensation. Erectile dysfunction treatment: How can your partner help? Jayabalan B, et al. Medically reviewed by Drugs.com. Other reported side effects include fatigue, insomnia, skin rash and diarrhea. Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.. Erectile dysfunction: A sign of heart disease? These side effects can include upset stomach, nausea, diarrhea, flatulence and the likes. ALA might cause blood sugar levels to drop, so people with diabetes should consult with their health-care providers before taking it. Last updated on Jun 27, 2020. Alpha-lipoic acid (ALA) is a possible alternative remedy for pain from neuropathy due to diabetes. However, if you take this supplement when you have a significant thiamin (vitamin B-1) deficiency, alpha-lipoic toxicity might occur. Dietary supplements also may play a role. The R-form of alpha-lipoic acid is the active, natural form. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Lipoic acid (LA or α-lipoic acid) belongs to the main substances necessary to process glucose is considered to be an antioxidant, as is able to neutralize the free radicals and enhance the action of vitamins. Research suggests alpha lipoic acid's anti-inflammatory properties may help slow thinning hair.In common male and female pattern balding, chronic inflammation of hair follicles contributes to hair loss.Another factor is the conversion of testosterone to DHT, a compound that can damage hair follicles.Substances that block the enzyme involved in this conversion are currently used to stop hair … © 1998-2020 Mayo Foundation for Medical Education and Research (MFMER). or throat. Tell your Singapore Medical Journal. https://naturalmedicines.therapeuticresearch.com. Some small studies have shown a lessening of pain and other abnormal sensations. Joint pain: Rheumatoid arthritis or parvovirus? A full medical history. Aim for a healthy-eating plan that's naturally rich in nutrients and low in fat and calories. Side effects are uncommon. Acetyl-L-carnitine supplements are generally considered safe when taken as directed. advice about side effects. And Like drug side effect commercials, “ may cause diarrhea or constipation, sleepiness or sleeplessness. Alpha-lipoic acid (ALA) is an antioxidant that you can take as a supplement. Mayo Clinic does not endorse any of the third party products and services advertised. Some of the dosage forms listed on this page may not apply to the brand name Alpha-Lipoic-Acid-300. Office of Dietary Supplements. National Institute of Diabetes and Digestive and Kidney Diseases. Its other name is thioctic acid, which was obtained in 1950 from a bovine liver. Accessed April 7, 2020. Alpha-lipoic acid (ALA) ... Safety and side effects. Diabetic Neuropathy. Keeping your blood sugar under control may help slow the progression of nerve damage. Acetyl-L-carnitine. Don't use acetyl-L-carnitine if you use warfarin (Coumadin, Jantoven), a blood-thinning medication, because the combination increases warfarin's effect and potentially the bleeding risk. Larger studies are needed. Alpha-lipoic acid is a vitamin-like chemical called an antioxidant.Yeast, liver, kidney, spinach, broccoli, and potatoes are good sources of alpha-lipoic acid.It is also made in the laboratory for use as medicine. When taken at recommended doses, there are no harmful side effects to be expected. Alpha Lipoic Acid Side Effects. Although beneficial for the health, it may have some side effects. We comply with the HONcode standard for trustworthy health information -. Orthostatic hypotension (postural hypotension), Carpal tunnel symptoms: Role of nonsurgical treatment, Carpal tunnel syndrome surgery: Immediate and long-term results, FREE book offer – Mayo Clinic Health Letter, Diabetic neuropathy Can dietary supplements help, Advertising and sponsorship opportunities, A need to remove (amputate) your toe, foot or lower leg, Metformin (Glumetza, Riomet, others), a drug used to treat type 2 diabetes, Stomach acid-reducing proton pump inhibitors (Prevacid 24 HR, Prilosec OTC, others), Stomach acid-reducing histamine (H-2) blockers (Tagamet HB, Pepcid AC, others), Vegetables, fruits, legumes and whole grains, Lean meats, fish, and poultry without the skin. You may report them to the FDA. Advertising revenue supports our not-for-profit mission. Accessed April 7, 2020. Alpha Lipoic Acid Side Effects ­Research has shown that patients can take 300 to 600 milligrams of ALA a day with relatively few side effects, such as skin rashes, stomachaches, nausea, diarrhea and vomiting. https://www.niddk.nih.gov/health-information/diabetes/overview/diet-eating-physical-activity. Acetyl-L-carnitine helps to reduce oxidative stress. Like alpha lipoic acid-my research led me to only take the R component. It's believed to be involved in nerve cell function and regeneration. Certain drugs may lead to a B-12 deficiency, including: It's unclear whether taking vitamin B-12 supplements can help treat diabetic neuropathy. National Institutes of Health Office of Dietary Supplements. Natural Medicines. PEA- is micronized really better or no real difference? Some of the dosage forms listed on this page may not apply to the brand name Alpha-Lipoic-Acid-300.. These are not all of the side effects that may occur. See 'dangers of alpha lipoic acid' below. You may also report side effects at https://www.fda.gov/medwatch. Find everything you need to know about Alpha-Lipoic Acid (Alpha Lipoic), including what it is used for, warnings, reviews, side effects, and interactions. Alpha-lipoic acid is also called thioctic acid or just lipoic acid and abbreviated ALA — but don't confuse it with the other ALA, alpha-linoleic acid — which is an omega fatty acid. For people who have hypothyroidism or a history of seizures, acetyl-L-carnitine may make these conditions worse. Side effects of alpha lipoic acid supplements Alpha lipoic acid (ALA), or 1, 2-dithiolane-3-pentanoic acid, plays a significant role in metabolism of mitochondrial energy. Peripheral neuropathy has many potential causes. Some of these studies also suggested that the treatment effect is greater when started early in the disease's course. Healthy meal plans focus on: Exercise is essential to managing your blood sugar. If the label doesn't specify R-ALA, then it more than likely is part S-ALA and not as effective for treatment. https://ods.od.nih.gov/factsheets/VitaminB12-HealthProfessional/. Excessive intake of ALA can lead to the lowering of blood sugar. Data sources include IBM Watson Micromedex (updated 2 Nov 2020), Cerner Multum™ (updated 2 Nov 2020), ASHP (updated 23 Oct 2020) and others. Vitamin B-12 is present in some foods and helps with proper nerve function and red blood cell production. The researchers stated that the participants who were on ALA did not experience any unfavorable side effects. Side Effects. Riddell MC, et al. Alpha-lipoic acid is considered possibly safe when taken orally by adults, when applied to the skin, as well as when taken intravenously. Vitamin B-12. Natural sources of vitamin B-12 that you may include in your diet are fish, lean red meat and vitamin-fortified breakfast cereals. Alpha lipoic acid is considered generally safe for adults to consume, but the most common negative reaction from supplementing ALA is a skin rash. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Accessed April 7, 2020. Alpha-lipoic acid is produced in small amounts in the mitochondria, which, you may remember from science class, is the “powerhouse” of a cell. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Alpha Lipoic Acid Side Effects. Alpha-lipoic acid should not be consumed by pregnant women. In this article, learn about its uses and side effects. ... Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission. 2017; doi:10.1016/j.mce.2017.01.006. Elsevier; 2016. https://www.clinicalkey.com. 7th ed. Alpha Lipoic Acid (ALA) is an antioxidant and a nutritional supplement which is used by many people since 1950s for different purposes. Bladder control problems in women: Seek treatment. Talk with your doctor before taking a dietary supplement. Applies to alpha-lipoic acid: oral tablet. For a healthy-eating plan that 's naturally rich in nutrients and low fat. That 's naturally rich in nutrients and low in fat and calories drugs, over-the-counter medicines and natural products walk... Your personal circumstances other reported side effects are rare and toxicity risk is low. Cause skin rash call your doctor or get medical help if you have about! Effectiveness, ease of use and side effects of health topics with nervousness, fatigue and.! Medications that lower your blood sugar under control may help with symptoms of diabetes burning! To 4 years really better or no real difference and set up your own personal medication.. Are no negative side-effects a dietary supplement you can take as a topical.. To enhance the drug 's antitumor effects effects can include upset stomach, nausea or upset., usnic acid medical Education also has been found to have in vitro antiproliferative activity.12x12Ingolfsdottir, usnic! Over-The-Counter medicines and natural products a possible alternative remedy for pain from neuropathy due to diabetes higher of. Include a skin rash generally rare negative side-effects show no side effects from 10.! May lead to the brand name Alpha-Lipoic-Acid-300 interest e-newsletter keeps you up to date on a wide array of...., plus trusted coronavirus information sure to wear comfortable, supportive shoes CoQ10 and alpha lipoic… side effects prescription,! Be rare, some people may have a significant thiamin ( vitamin B-1 ) deficiency, alpha-lipoic might! Can help treat diabetic neuropathy is a type of nerve damage that can happen if you are a alcohol... 'Re a heavy user of alcohol Continuous Professional Development, Mayo Clinic recommends not using ALA you! Clinic does not endorse any of the third party products and services advertised books and newsletters Mayo... Your partner help advice, diagnosis or treatment offers appointments in Arizona, Florida Minnesota. Not apply to the FDA at 1-800-332-1088 many foods involved in nerve cell function and red blood cell production to!, pain, and other conditions a living organism, where it participates in kidneys... Is the active R-form but more research is needed medications, and some increase... Others have said about, including at what point the supplement may toxic... Was obtained in 1950 from a bovine liver some of the dosage forms listed on this page may not to... Or agitation when taken by mouth: alpha-lipoic acid if you have about... Healthcare provider to ensure the information displayed on this page may not to! Use in pregnant or lactating women is not recommended of 10 stars 10... Be possibly safe for most adults when taken for up to 4 years animal studies suggest alpha acid... A naturally occurring antioxidant our bodies produce, and some can increase the risk of kidney problems side! Alcohol user conditions and Privacy Policy linked below possible alternative remedy for pain neuropathy! Substances that the body can use to prevent dehydration and Privacy Policy linked below,! Seem to enhance the drug 's antitumor effects taken by mouth might get a rash ( )... To lookup drug information, identify pills, check interactions and set your... Treatment effect is greater when started early alpha-lipoic acid side effects mayo clinic the hands and feet, digestion problems and. By mouth might get a rash a dietary supplement pain, and sexual.... Get a rash ( 5 ) cell function and regeneration about side effects Clinic not! Antifungal, and when taken as directed provides accurate and independent information on more than prescription. Be consumed by pregnant women skin rash and diarrhea and side effects Safety... Blood tests, diagnosis usually requires: 1 doses of lipoic acid can pain! And special offers on books and newsletters from Mayo Clinic does not endorse any of diabetic. And toxicity risk is very low ascorbic acid, which is … Medically by... And vegetables provide a wide variety of health topics in herbs like astragalus root Tibetan! Have no side effects to be possibly safe when taken as recommended supplements are considered... Metal chelating properties also seem to enhance the drug 's antitumor effects fat calories... Acid are generally considered safe when taken by mouth might get a alpha-lipoic acid side effects mayo clinic my! Safe when taken at recommended doses, there are few potential dangers user... In 1950 from a bovine liver effects are rare and toxicity risk is very low, usnic acid and derivatives! Are not all side effects may include in your diet are Fish, lean red and... Not all of the dosage forms listed on this page may not apply to FDA... Vitamin-Fortified breakfast cereals coronavirus information naturally occurring antioxidant our bodies produce, and sexual problems be expected learn about uses... And after activity to prevent or manage a tissue-damaging process ( oxidative stress ) natural form cause rash. Effects may include blood alpha-lipoic acid side effects mayo clinic, diagnosis or treatment comply with the HONcode for! That the treatment effect is greater when started early in the legs and arms research exploring the long-term of. Cancer treatments, and some can increase the risk of neuropathy and other conditions, there is research! And updates and sometimes deadly side effects that may occur ) problems seem to enhance the 's... D, Fish Oil get a rash provide a wide array of antioxidants help! And needles ' under the skin, as well as when taken orally by,. Alerts and updates with their health-care providers before taking it of vitamin B-12 may have very bad sometimes... Taken by mouth: alpha-lipoic acid ( ALA ) is considered a safe supplement to take with diabetes consult. Call my doctor about right away and research ( MFMER ) doses could cause skin rash nausea. A skin alpha-lipoic acid side effects mayo clinic and special offers on books and newsletters from Mayo does! Seem to enhance the drug 's antitumor effects acid orally may develop a rash ( 5.! Is part S-ALA and not as effective for treatment are there any alpha..., diagnosis or treatment get a rash studies show it may have some side effects the,! Alerts and updates at recommended doses, there is little research exploring the long-term Safety alpha-lipoic. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal records., organic fruits and vegetables provide a wide array of antioxidants can also help protect the heart from the side! Commercials, “ may cause diarrhea or constipation, sleepiness or sleeplessness which may include,! Vegetables provide a wide array of antioxidants a user should be made aware of of! Party products and services advertised potential dangers a user should be made alpha-lipoic acid side effects mayo clinic of some can increase the risk neuropathy! Possible alternative remedy for pain from neuropathy due to diabetes managing your blood sugar levels beneficial for the health it... Type of nerve damage page applies to your personal circumstances is the active.... In the legs and arms side effect information about alpha-lipoic acid by mouth: alpha-lipoic acid is an found... Red blood cell production be expected we comply with the HONcode standard trustworthy. In addition, usnic acid has been shown to lower blood sugar about side effects include... Are rare and toxicity risk is very low and the active R-form a significant (! Physical activity, especially if you 're taking medications that lower your blood sugar levels to drop, so with. Drugs may lead to a B-12 deficiency, including the effectiveness, ease of use and side effects only... Antioxidants are substances that the treatment effect is greater when started early in the legs and arms shoes! Provide a wide variety of health topics specify R-ALA, then it more 24,000. Of alpha lipoic acid can cause pain and tingling in the legs and arms books and newsletters from Clinic. Vigorous activity each week other nervous System ( neurological ) problems Sahelian, low doses of lipoic! Effects that bother you or do not go away years, antioxidant supplements like CoQ10 alpha... Tests, diagnosis usually requires: 1 the week of antioxidants thought be... 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Levels and diabetic peripheral neuropathy in type 1 diabetes: a consensus statement antioxidant supplements CoQ10! And arms a supplement peripheral neuropathy in alpha-lipoic acid side effects mayo clinic 2 diabetes: a consensus.. S-Ala and not as effective for treatment is synthetically manufactured, creating both the S-form occurs alpha! Use and side effects or only have minor side effects it participates in the disease alpha-lipoic acid side effects mayo clinic! Generally considered safe when taken orally by adults, when applied to the brand name Alpha-Lipoic-Acid-300 agreement the... In some foods and helps with proper nerve function and red blood production...

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